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Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration.

Saurat N, Minotti AP, Rahman MT, Sikder T, Zhang C, Cornacchia D, Jungverdorben J, Ciceri G, Betel D, Studer L
Cell Stem Cell. 2024 Aug 1;31(8):1162-1174.e8. doi: 10.1016/j.stem.2024.06.001. Epub 2024 Jun 24. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
235659pLV_EF1a-NAE1_IRES_Purohuman NAE1 cloned into into lentiviral backbone (pLV-EF1a-IRES-Puro)
235660pLV_EF1aUBA3_IRES_Purohuman UBA3 cloned into pLV-EF1a-IRES-Puro vector (Addgene: 85132)

Antibodies from Article