Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function.
Miller LVC, Papa G, Vaysburd M, Cheng S, Sweeney PW, Smith A, Franco C, Katsinelos T, Huang M, Sanford SAI, Benn J, Farnsworth J, Higginson K, Joyner H, McEwan WA, James LC
Cell. 2024 Oct 17;187(21):5967-5980.e17. doi: 10.1016/j.cell.2024.08.024. Epub 2024 Sep 13.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 233688 | pSMPPv2-Tau-RING | Expression of Tau-RING protein in mammalian cells |
| 233689 | pLVX-Tau-mCherry-RING | Inducible expression of Tau-mCherry-RING |
| 233690 | pSMPPv2-Tau-RING (M72E/I18R) | Expression of Tau-RING I18R-M72E mutant in mammalian cells |
| 233691 | pOPTG-Tau-RING | Expression of Tau-RING protein in bacteria |
| 233692 | pOPTG-Tau-RING (M72E/I18R) | Expression of Tau-RING I18R-M72E mutant in bacterial cells |
| 233693 | AAV 9P31-hSyn-Venus-P2A-Tau-RING | AAV expression of Venus-P2A-Tau-RING from hSyn promoter |
| 233694 | AAV 9P31-hSyn-Venus-P2A-Tau-RING I18R/M72E | AAV expression of Venus-P2A-Tau-RING-I18R/M72E from hSyn promoter |
| 233695 | AAV PHP.eB-CAG-Venus | AAV expression of Venus from CAG promoter |
| 233696 | AAV PHP.eB-CAG-Venus-P2A-Tau-RING | AAV expression of Venus-P2A-Tau-RING from CAG promoter |