Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia.
Chen Z, Zhou K, Xue J, Small A, Xiao G, Nguyen LXT, Zhang Z, Prince E, Weng H, Huang H, Zhao Z, Qing Y, Shen C, Li W, Han L, Tan B, Su R, Qin H, Li Y, Wu D, Gu Z, Ngo VN, He X, Chao J, Leung K, Wang K, Dong L, Qin X, Cai Z, Sheng Y, Chen Y, Wu X, Zhang B, Shi Y, Marcucci G, Qian Z, Xu M, Muschen M, Chen J, Deng X
Sci Transl Med. 2023 Mar 29;15(689):eabq8513. doi: 10.1126/scitranslmed.abq8513. Epub 2023 Mar 29.
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Plasmids from Article
ID | Plasmid | Purpose |
---|---|---|
232941 | pCDH-no-Flag-TET1-S-WT | Expresses short isoform of TET1 in mammalian cells in its wild-type form |
232943 | pCDH-3_Flag-TET1-S-MUT | Expresses mutant form of the short isoform of TET1 in mammalian cells |