An engineered cereblon optimized for high throughput screening and molecular glue discovery.
Bailey HJ, Eisert J, Kazi R, Gerhartz J, Pienkowska DE, Dressel I, Vollrath J, Kondratov I, Matviyuk T, Tolmachova N, Shah VJ, Giuliani G, Mosler T, Geiger TM, Esteves AM, Santos SP, Sousa RL, Bandeiras TM, Leibrock EM, Bauer U, Leuthner B, Langer JD, Wegener AA, Nowak RP, Sorrell FJ, Dikic I
Cell Chem Biol. 2024 Nov 20:S2451-9456(24)00460-4. doi: 10.1016/j.chembiol.2024.11.002.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 232779 | CRBN_ΔHBD | Expresses CRBN_ΔHBD sequence in E. coli cells with cleavable MBP-His tag and deleted internal DDB1 binding domain |