Gain-of-function enhancer variant near KCNB1 causes familial ST-depression syndrome.
Christensen AH, Pan G, Marvig RL, Rodriguez Gonzalez FG, Vissing CR, Silajdzija E, Frosted R, Girma EG, Gabrielaite M, Jensen HK, Rossing K, Henriksen FL, Sandgaard NCF, Ahlberg G, Ghouse J, Lundegaard PR, Weischenfeldt J, Wadelius C, Bundgaard H
Eur Heart J. 2025 Apr 10:ehaf213. doi: 10.1093/eurheartj/ehaf213.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 232623 | lentiGuide-chr20-49345720-gRNA1 | Lentiviral plasmid expressing gRNA targeting the enhancer region in Chr20:49345720 (hg38) locus with lentiGuide-Hygro-eGFP (Addgene #99375) as backbone. |
| 232624 | lentiGuide-chr20-49345720-gRNA2 | Lentiviral plasmid expressing gRNA targeting the enhancer region in Chr20:49345720 (hg38) locus with lentiGuide-Hygro-eGFP (Addgene #99375) as backbone. |
| 232625 | lentiGuide-chr20-49345720-gRNA3 | Lentiviral plasmid expressing gRNA targeting the enhancer region in Chr20:49345720 (hg38) locus with lentiGuide-Hygro-eGFP (Addgene #99375) as backbone. |
| 232626 | pBMN-MEF2A | Lentiviral plasmid expressing human MEF2A. |
| 232627 | pBMN-MEF2C | Lentiviral plasmid expressing mouse MEF2C. |
| 232628 | pBMN-MEF2D | Lentiviral plasmid expressing mouse MEF2D. |
| 232629 | pBMN-SRF | Lentiviral plasmid expressing human SRF. |