The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells.
Wolf G, Craigon C, Teoh ST, Essletzbichler P, Onstein S, Cassidy D, Uijttewaal ECH, Dvorak V, Cao Y, Bensimon A, Elling U, Ciulli A, Superti-Furga G
Cell Chem Biol. 2024 Dec 24:S2451-9456(24)00489-6. doi: 10.1016/j.chembiol.2024.11.009.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 213694 | Human SLC overexpression library | Inducible barcoded library with 467 codon-optimized cDNAs with UMIs to test the impact of SLC transporters on biological processes. |
| 221409 | Human Transporter Knockout Library with UMIs | gRNA library to test the impact of transporters on biological processes |
| 221410 | Human ABC Transporter Knockout Sub-library with UMIs | gRNA library to test the impact of transporters on biological processes (subset: ABC transporters and controls) |
| 221423 | pENTR-ABCC1_STOP | Gateway entry clone with codon-optimized ORF sequence for subcloning into custom expression vectors |
| 221424 | pENTR-ABCB1_STOP | Gateway entry clone with codon-optimized ORF sequence for subcloning into custom expression vectors |
| 221425 | pENTR-ABCF2_STOP | Gateway entry clone with codon-optimized ORF sequence for subcloning into custom expression vectors |