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Orthogonalized human protease control of secreted signals.

Aldrete CA, Call CC, Sant'Anna LE, Vlahos AE, Pei J, Cong Q, Gao XJ
Nat Chem Biol. 2025 Jan 15. doi: 10.1038/s41589-024-01831-x. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
231186CMVTO-g0Non-coding DNA plasmid control
231187CA-0039 CMVTO-hIL10 (Fused Dimer)Fused human IL-10 dimer
231188CA-0046 CMVTO-hIL10dimer-rens-IL10RaFused cageIL-10-dimer
231189CA-0030 CMVTO-Renin-ECLMembrane-bound human renin
231190CA-0045 CMVTO-mono-hIL10 (R5A11M)Mutant human IL-10 monomer
231191CA-0091 CMVTO-mono-hIL10-R5A11M-rens-3GS-IL10RaCageIL-10-monomer
231192CA-0033 CMVTO-hIL6Human IL-6
231193CA-0200 CMVTO-hIL6Ra_M4-rens-hIL6CageIL-6 (N-term)
231194CA-0216 CMVTO-hIL6Ra_M4-rens-hIL6-rens-IL6RbMulti-cageIL-6
231196CA-0165 CMVTO-mono-hIL10 (R5A11M)-rensCleaveIL-10
231197CA-0201 CMVTO-hIL6-rens.1CleaveIL-6
231198CA-0234 CMVTO-sumIL2-rensGS.3CleaveIL-2
231199CA-0140 CMVTO-Renin-ECL-CD4-tevs-RXR6.2ER-retained renin
231200CA-0113 CMVTO-Renin(mouse)-ECLMembrane-bound mouse renin
231201CA-0151 CMVTO-Renin(H2M)-ECLMembrane-bound human-to-mouse (H2M) renin
231202CA-0176 CMVTO-mono-hIL10-R5A11M-mouse_rens-3GS-IL10RaCageIL-10-mono (mouse renin cut-site)
231203CA-0193 CMVTO-Renin(H2M)-ECL-CD4-tevs-RXR6.2ER-retained H2M renin
231204CA-0192 CMVTO-Renin(mouse)-ECL-CD4-tevs-RXR6.2ER-retained mouse renin
231205CA244 CMVTO_ERret-H2M-Renin_T2A_mRens-cageIL-10-c-myc_T2A-mCherrySingle transcript cageIL-10 (mRens) + ER-renin (H2M)
231206CA245 CMVTO_ERret-H2M-Renin_P2A_mRens-hIL6-rens.1_T2A_mRens-cageIL-10-c-myc_T2A-mCherrySingle transcript cageIL-10 (mRens) + cleaveIL-6 (mRens) + ER-renin (H2M)
231207CA-0230 EF1a_Puro_ERret-H2M-Renin_T2A_mRens-cageIL-10-c-myc_T2A-mCherry_Gen2Single transcript cageIL-10 (mRens) + ER-renin (H2M) (Lenti)
231208CA-0248 EF1a_mRens-cageIL-2-c-myc_T2A_ERret-H2M-Renin_T2A-mCherry_Gen2Single transcript cageIL-2 (mRens) + ER-renin (H2M) (Lenti)
231209CA-0266 CMVTO-IVT-UTR-mRens-cageIL-2-c-myc_T2A_ERret-H2M-Renin (FLP-IN)Single transcript mRNA cageIL-2 (mRens) + ER-renin (H2M)
231211CA-0194 CMVTO-secNLuc-rens-memMembrane-bound nanoluciferase
231212CMVTO-SEAPSecreted Embryonic Alkaline Phosphatase
231213CA253 CMVTO-rens-3GS-IL10Ra-c-mycCleaved IL-10Ra-myc
231214CA173 CMVTO-mono-hIL10-R5A11M-rens-3GS-IL10Ra-c-mycCageIL-10-myc
231215CA-0252 CMVTO-c-myc-mono-hIL10 (R5A11M)-rens-cleavedCleaved-myc-IL-10
231216CA-0251 CMVTO-c-myc-mono-hIL10 (R5A11M)-rensmyc-CleaveIL-10
231217CA-0034 CMVTO-hIL6-rens-hIL6Ra_M4C-CageIL-6
231218CA-0064 CMVTO-SumIL2-noGS-rens-IL2RbCageIL-2 (N-term 0 AA)
231219CA-0061 CMVTO-SumIL2-2GS-rens-IL2RbCageIL-2 (N-term 10 AA)
231220CA-0062 CMVTO-SumIL2-3GS-rens-IL2RbCageIL-2 (N-term 15 AA)
231221CA-0063 CMVTO-SumIL2-5GS-rens-IL2RbCageIL-2 (N-term 25 AA)
231222CA-0057 CMVTO-SumIL2-rens-2GS-IL2RbCageIL-2 (C-term 10 AA)
231223CA-0058 CMVTO-SumIL2-rens-3GS-IL2RbCageIL-2 (C-term 15 AA)
231224CA-0059 CMVTO-SumIL2-rens-5GS-IL2RbCageIL-2 (C-term 25 AA)
231225CA-0202 CMVTO-hIL6-rens.1_DelCleaveIL-6_Del
231226CMVTO-hIL2 (AV)hIL2
231227CA-0210 CMVTO-hIL2-rens-del.1CleaveIL-2_loop1_del
231228CA-0211 CMVTO-hIL2-rens-del.2CleaveIL-2_loop3_del
231229CA-0212 CMVTO-hIL2-rens-del.3CleaveIL-2_loop2_del

Antibodies from Article