Bile Acid Receptor Agonist Reverses Transforming Growth Factor-beta1-Mediated Fibrogenesis in Human Induced Pluripotent Stem Cells-Derived Kidney Organoids.
Yang X, Delsante M, Daneshpajouhnejad P, Fenaroli P, Mandell KP, Wang X, Takahashi S, Halushka MK, Kopp JB, Levi M, Rosenberg AZ
Lab Invest. 2024 May;104(5):100336. doi: 10.1016/j.labinv.2024.100336. Epub 2024 Jan 22.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 230915 | PGL4.11-COL1A1WT | Expression of human COL1A1 promoter and testing the promoter activity with luciferase assay. |
| 230916 | PGL4.11-COL1A1mTEAD | Comparing with wild type COL1A1 promoter, tested whether mutant TEAD binding sites changed the promoter activity. |
| 230917 | PGL4.11-COL1A1mSMAD | Tested the COL1A1 promoter activity after abolition of the proximal SMAD binding sites in the promoter. |
| 230918 | PGL4.11-COL1A1double mutants | Double mutation of TEAD and SMAD binding elements in COL1A1 promoter; check the promoter activity. |