Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits.
Hunker AC, Wirthlin ME, Gill G, Johansen NJ, Hooper M, Omstead V, Taskin N, Weed N, Vargas S, Bendrick JL, Gore B, Ben-Simon Y, Bishaw Y, Opitz-Araya X, Martinez RA, Way S, Thyagarajan B, Lerma MN, Laird W, Sven O, Sanchez REA, Alexander JR, Amaya A, Amster A, Ayala A, Baker PM, Barcelli T, Barta S, Bertagnolli D, Bielstein C, Bishwakarma P, Bowlus J, Boyer G, Brouner K, Casian B, Casper T, Chakka AB, Chakrabarty R, Clark M, Colbert K, Daniel S, Dawe T, Departee M, DiValentin P, Donadio NP, Dotson NI, Dwivedi D, Egdorf T, Fliss T, Gary A, Goldy J, Grasso C, Groce EL, Gudsnuk K, Han W, Haradon Z, Hastings S, Helback O, Ho WV, Huang C, Johnson T, Jones DL, Juneau Z, Kenney J, Leibly M, Li S, Liang E, Loeffler H, Lusk NA, Madigan Z, Malloy J, Malone J, McCue R, Melchor J, Mich JK, Moosman S, Morin E, Naidoo R, Newman D, Ngo K, Nguyen K, Oster AL, Ouellette B, Oyama AA, Pena N, Pham T, Phillips E, Pom C, Potekhina L, Ransford S, Reding M, Rette DF, Reynoldson C, Rimorin C, Rios Sigler A, Rocha DB, Ronellenfitch K, Ruiz A, Sawyer L, Sevigny J, Shapovalova NV, Shepard N, Shulga L, Soliman S, Staats B, Taormina MJ, Tieu M, Wang Y, Wilkes J, Wood T, Zhou T, Williford A, Dee N, Mollenkopf T, Ng L, Esposito L, Kalmbach B, Yao S, Ariza J, Mufti S, Smith K, Waters J, Ersing I, Patrick M, Zeng H, Lein ES, Kojima Y, Horwitz G, Owen SF, Levi BP, Daigle TL, Tasic B, Bakken TE, Ting JT
bioRxiv [Preprint]. 2024 Sep 29:2024.09.27.615553. doi: 10.1101/2024.09.27.615553.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 230862 | AiP12909: pAAV-AiE0445h_3xC2-minBG-SYFP2-WPRE3-BGHpA (Alias: CN2909) | AiE0445h_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal indirect pathway MSNs (D2-MSNs) |
| 230863 | AiP13045: pAAV-AiE0779m_3xC3-minBG-SYFP2-WPRE3-BGHpA (Alias: CN3045) | AiE0779m_3xC3 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal MSNs |
| 230864 | AiP13640: pAAV-AiE0949h-minBG-SYFP2-P2A-3XFLAG-10aa-H2B-WPRE3-BGHpA (Alias: CN3640) | AiE0949h is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal neuron subset |
| 230865 | AiP13985: pAAV-AiE0445h_3xC2-minBG-jRGECO1a-WPRE3-BGHpA (Alias: CN3985) | AiE0445h_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal indirect pathway MSNs (D2-MSNs) |
| 230866 | AiP14034: pAAV-AiE0445h_3xC2-minBG-CoChR-EGFP-WPRE3-BGHpA (Alias: CN4034) | AiE0445h_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal indirect pathway MSNs (D2-MSNs) |
| 230867 | AiP14133: pAAV-AiE0445h_3xC2-minBG-jGCaMP8m-WPRE3-BGHpA (Alias: CN4133) | AiE0445h_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal indirect pathway MSNs (D2-MSNs) |
| 230868 | AiP14210: pAAV-AiE0779m_3xC2-minBG-SYFP2-P2A-mScarlet-10aa-H2B-WPRE3-BGHpA (Alias: CN4210) | AiE0779m_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal direct pathway MSNs (D1-MSNs) |
| 230869 | AiP14530: pAAV-AiE0743m_3xC2-minBG-mTFP1-WPRE3-BGHpA (Alias: CN4530) | AiE0743m_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal cholinergic interneurons |
| 230870 | AiP14531: pAAV-hDLX_C2.1-minBG-mTFP1-WPRE3-BGHpA (Alias: CN4531) | hDLX_C2.1 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal cholinergic interneurons |
| 230871 | AiP14573: pAAV-AiE0452h-minBG-FlpO-WPRE3-BGHpA (Alias: CN4573) | AiE0452h is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal indirect pathway MSNs (D2-MSNs) |
| 230872 | AiP14646: pAAV-AiE0779m_6xC2-minBG-jGCaMP8s-WPRE3-BGHpA (Alias: CN4646) | AiE0779m_6xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal direct pathway MSNs (D1-MSNs) |
| 230873 | AiP15100: pAAV-AiE0140h_3xC2-minBG-FlpO-4X2C-WPRE3-BGHpA (Alias: CN5100) | AiE0140h_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in cortical and striatal Pvalb interneurons |
| 230874 | AiP15381: pAAV-AiE0873m_3xC2-minBG-SYFP2-P2A-mScarlet-10aa-H2B-WPRE3-BGHpA (Alias: CN5381) | AiE0873m_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal cholinergic interneurons |
| 230875 | AiP15385: pAAV-AiE0873m_3xC2-minBG-mScarlet-WPRE3-BGHpA (Alias: CN5385) | AiE0873m_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal cholinergic interneurons |
| 230876 | AiP15481: pAAV-AiE0140h_3xC2-minBG-iCre(R297T)-4X2C-BGHpA (Alias: CN5481) | AiE0140h_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal Pvalb interneurons |
| 230877 | AiP15571: pAAV-AiE1426m-minBG-iCre(R297T)-BGHpA (Alias: CN5571) | AiE1426m is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal Sst-Chodl interneurons |
| 230878 | AiP15582: pAAV-AiE0780m-minBG-jRGECO1a-WPRE3-BGHpA (Alias: CN5582) | AiE0780m is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal direct pathway MSNs (D1-MSNs) |
| 230879 | AiP15649: pAAV-AiE0780m_3xC2-minBG-SYFP2-WPRE3-BGHpA (Alias: CN5649) | AiE0780m_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal direct pathway MSNs (D1-MSNs) |
| 230880 | AiP15745: pAAV-AiE0452h-minBG-mScarlet-WPRE3-BGHpA (Alias: CN5745) | AiE0452h is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal indirect pathway MSNs (D2-MSNs) |
| 230881 | AiP15746: pAAV-AiE0780m-minBG-mScarlet-WPRE3-BGHpA (Alias: CN5746) | AiE0780m is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal direct pathway MSNs (D1-MSNs) |
| 230882 | AiP15747: pAAV-AiE0779m_3xC2-minBG-mScarlet-WPRE3-BGHpA (Alias: CN5747) | AiE0779m_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal direct pathway MSNs (D1-MSNs) |
| 230883 | AiP15645: pAAV-AiE1426m_3xC1-minBG-SYFP2-WPRE3-BGHpA (Alias: CN5645) | AiE1426m_3xC1 is an enhancer sequence, designed to drive AAV-mediated transgene expression in striatal Sst-Chodl neurons |
| 230884 | AiP15646: pAAV-AiE1426m_3xC2-minBG-SYFP2-WPRE3-BGHpA (Alias: CN5646) | AiE1426m_3xC2 is an enhancer sequence, designed to drive AAV-mediated transgene expression in cortical and striatal Sst-Chodl neurons |