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Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2.

Raig ND, Surridge KJ, Sanz-Murillo M, Dederer V, Kramer A, Schwalm MP, Elson L, Chatterjee D, Mathea S, Hanke T, Leschziner AE, Reck-Peterson SL, Knapp S
bioRxiv [Preprint]. 2025 Feb 13:2024.09.17.613365. doi: 10.1101/2024.09.17.613365. (Link opens in a new window) PubMed (Link opens in a new window) Article


Plasmids from this article have been deposited by multiple labs. See below for all materials from each lab:

  • Sebastian Mathea
  • Samara Reck-Peterson

    • Plasmids from Article

    ID Plasmid Purpose
    228879pFB-EPCP5Expression of Z-tagged LRRK2 KW using Baculoviruses
    228880pET28A-Rab8AExpression of His-tagged Rab8A in E. coli
    231174pcDNA5 FRT TO GFP11-LRRK2Expresses GFP-11-LRRK2 (wildtype, full length) in mammalian cells
    231175pcDNA5 FRT TO GFP11-LRRK2_G2019SExpresses GFP-11-LRRK2 G2019S in mammalian cells

    Antibodies from Article