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Directed evolution of engineered virus-like particles with improved production and transduction efficiencies.

Raguram A, An M, Chen PZ, Liu DR
Nat Biotechnol. 2024 Nov 13. doi: 10.1038/s41587-024-02467-x. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
228466v5 eVLP gag-pro-polExpresses MMLVgag-pro-pol(Q226P) for producing v5 eVLPs
228467v5 ABE-eVLPExpresses MMLVgag(C507V)–ABE8e for producing v5 ABE-eVLPs
228468v5 Cas9-eVLPExpresses MMLVgag(C507V)–Cas9 for producing v5 Cas9-eVLPs

Antibodies from Article