Ibetazol, a novel inhibitor of importin beta1-mediated nuclear import.
Vercruysse T, Vanstreels E, Jacquemyn M, Boland S, Kilonda A, Allasia S, Vandecaetsbeek I, Klaassen H, Versele M, Chaltin P, Marchand A, Daelemans D
Commun Biol. 2024 Nov 23;7(1):1560. doi: 10.1038/s42003-024-07237-8.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 228398 | pGL4-CMV-NLS/cMyc-AcGFP2x-NES/iKB2-P2A-Puro | Encodes NLS/cMyc-AcGFP2x-NES/iKB2 which is a tandem of AcGFP with an N-terminal cMyc NLS and a C-terminal iKB2 NES that shuttles between the nucleus and the cytoplasm |
| 228399 | pGL4-CMV-3xFLAG-NLS/SV40-AcGFP-NES/PKI-P2A-Puro | Encodes 3xFLAG-NLS/SV40-AcGFP-NES/PKI which is a AcGFP with an N-terminal SV40 NLS and a C-terminal iKB2 NES that shuttles between the nucleus and the cytoplasm |
| 228400 | pcDNA3.1-CMV-Puro-P2A-NES/PKI-mNeonGreen2x-NLS/FUS | Encodes NES/PKI-mNeonGreen2x-NLS/FUS which is a tandem of mNeongreen with an N-terminal PKI NES and a C-terminal FUS NLS that shuttles between the nucleus and the cytoplasm |
| 228401 | pcDNA3.1-EF1A-mNeonGreen2x-SREBP1-P2A-Puro | Encodes a N-terminal truncated version of SREBP1 lacking part of the transcriptional activation domain and fused to a tandem of mNeongreen to visualize the import of SREBP1 |