Polypharmacological profiling across protein target families and cellular pathways using the multiplexed cell-based assay platform safetyProfiler reveals efficacy, potency and side effects of drugs.
Popovic L, Brankatschk B, Palladino G, Rossner MJ, Wehr MC
Biomed Pharmacother. 2024 Nov;180:117523. doi: 10.1016/j.biopha.2024.117523. Epub 2024 Oct 14.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 227098 | pBK_Gal4-DBD-Ar | Ar receptor overexpression for luciferase and barcode assays |
| 227099 | pBK_Gal4-DBD-ESR1 | ESR1 receptor overexpression for luciferase and barcode assays |
| 227101 | pTag4C_ADRA1A-V2R-NTEV-tcs-GV | ADRA1A receptor for split TEV assay |
| 227102 | pTag4C_AVPR1A-V2R-NTEV-tcs-GV | AVPR1A receptor for split TEV assay |
| 227103 | pTag4C_SP-DRD2-V2R-NTEV-tcs-GV-2xHA | DRD2 receptor for split TEV assay |
| 227104 | pTag4C_Nrg1-GV-2HA | Nrg1 protein for luciferase and barcode assays |
| 227105 | pcDNA3.1-Zeo_BACE1 | BACE1 enzyme overexpression for Nrg1 activation in luciferase and barcode assays |
| 227106 | pAAV_AR-RE_MLPmin_BC1011-luc2 | Androgen receptor response element for luciferase and barcode assays; barcode BC1011 |
| 227108 | pAAV_AR-RE_MLPmin_BC1014-luc2 | Androgen receptor response element for luciferase and barcode assays; barcode BC1014 |
| 227109 | pAAV_ER-RE_MLPmin_BC1063-luc2 | Estrogen receptor response element for luciferase and barcode assays; barcode BC1063 |
| 227111 | pAAV_ER-RE_MLPmin_BC1065-luc2 | Estrogen receptor response element for luciferase and barcode assays; barcode BC1065 |
| 227112 | pAAV_GR-RE_MLPmin_BC1092-luc2 | Glucocorticoid receptor response element for luciferase and barcode assays; barcode BC1092 |
| 227113 | pAAV_GR-RE_MLPmin_BC1093-luc2 | Glucocorticoid receptor response element for luciferase and barcode assays; barcode BC1093 |
| 227114 | pAAV_GR-RE_MLPmin_BC1094-luc2 | Glucocorticoid receptor response element for luciferase and barcode assays; barcode BC1094 |
| 227115 | pGL4_10xUAS-CMVmin-BC0396-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0396 |
| 227116 | pGL4_10xUAS-CMVmin-BC0397-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0397 |
| 227117 | pGL4_10xUAS-CMVmin-BC0400-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0400 |
| 227118 | pGL4_10xUAS-CMVmin-BC0405-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0405 |
| 227119 | pGL4_10xUAS-CMVmin-BC0407-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0407 |
| 227120 | pGL4_10xUAS-CMVmin-BC0408-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0408 |
| 227121 | pGL4_10xUAS-CMVmin-BC0410-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0410 |
| 227122 | pGL4_10xUAS-CMVmin-BC0411-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0411 |
| 227123 | pGL4_10xUAS-CMVmin-BC0431-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0431 |
| 227124 | pGL4_10xUAS-CMVmin-BC0432-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0432 |
| 227125 | pGL4_10xUAS-CMVmin-BC0434-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0434 |
| 227126 | pGL4_10xUAS-CMVmin-BC0436-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0436 |
| 227127 | pGL4_10xUAS-CMVmin-BC0439-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0439 |
| 227128 | pGL4_10xUAS-CMVmin-BC0440-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0440 |
| 227129 | pGL4_10xUAS-CMVmin-BC0441-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0441 |
| 227130 | pGL4_10xUAS-CMVmin-BC0442-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0442 |
| 227131 | pGL4_10xUAS-CMVmin-BC0443-luc2 | Barcoded assay, UAS sensor for split TEV assays; barcode BC0443 |
| 227132 | pGL4_CRE-CMVmin-BC0481-luc2 | Barcoded assay, cAMP/Ca2+ sensor; barcode BC0481 |
| 227134 | pGL4_CRE-CMVmin-BC0498-luc2 | Barcoded assay, cAMP/Ca2+ sensor; barcode BC0498 |
| 227135 | pGL4_CRE-CMVmin-BC0504-luc2 | Barcoded assay, cAMP/Ca2+ sensor; barcode BC0504 |
| 227136 | pGL4_EGR1p-BC0132-luc2 | Barcoded assay, MAPK sensor; barcode BC0132 |
| 227137 | pGL4_EGR1p-BC0136-luc2 | Barcoded assay, MAPK sensor; barcode BC0136 |
| 227138 | pGL4_EGR1p-BC1484-luc2 | Barcoded assay, MAPK sensor; barcode BC1484 |
| 227139 | pGL4_NFAT-RE-CMVmin-BC0524-luc2 | Barcoded assay, Ca2+ sensor; barcode BC0524 |