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A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2.

Dederer V, Sanz Murillo M, Karasmanis EP, Hatch KS, Chatterjee D, Preuss F, Abdul Azeez KR, Nguyen LV, Galicia C, Dreier B, Pluckthun A, Versees W, Mathea S, Leschziner AE, Reck-Peterson SL, Knapp S
J Biol Chem. 2024 Jul;300(7):107469. doi: 10.1016/j.jbc.2024.107469. Epub 2024 Jun 12. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
226783pFB-EPCP1Expression of Z-tagged LRRK2 RCKW using Baculoviruses
226784pQE30-DARPin-E11Expression of His-tagged DARPin E11 in E. coli
229019pCDNA5-LRRK2Expression of untagged full length human LRRK2 in mammalian cells

Antibodies from Article