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Genetic Screen in a Pre-Clinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities.

Freeland J, Munoz M, O'Donnell E, Langerman J, Darrow M, Bergonio J, Suarez-Navarro J, Thorpe S, Canter R, Randall RL, Plath K, Carraway KL, Witte ON, Graeber TG, Carr-Ascher JR
Clin Cancer Res. 2024 Aug 23. doi: 10.1158/1078-0432.CCR-24-1238. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
225873Control-Control-LRG-GFPTwo copies of guide RNA targeting a control sequence
225874Control-TP53-LRG-GFPGuides targeting P53 and a control sequence
225875Control-RB1-LRG-GFPGuides targeting RB1 and a control sequence
225876RB1-TP53-LRG-GFPGuides targeting TP53 and RB1

Antibodies from Article