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CD28 hinge used in chimeric antigen receptor (CAR) T-cells exhibits local structure and conformational exchange amidst global disorder.

Folimonova V, Chen X, Negi H, Schwieters CD, Li J, Byrd RA, Taylor N, Youkharibache P, Walters KJ
Commun Biol. 2024 Aug 31;7(1):1072. doi: 10.1038/s42003-024-06770-w. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
224929pGEX6P1-CD28 CAR hinge (I114 – P152)Expression GST fusion CD28 CAR hinge (I114-P152) in Escherichia coli.

Antibodies from Article