Development of covalent chemogenetic K(2P) channel activators.
Deal PE, Lee H, Mondal A, Lolicato M, Mendonca PRF, Black H, Jang S, El-Hilali X, Bryant C, Isacoff EY, Renslo AR, Minor DL Jr
Cell Chem Biol. 2024 Jul 18;31(7):1305-1323.e9. doi: 10.1016/j.chembiol.2024.06.006.
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Plasmids from Article
ID | Plasmid | Purpose |
---|---|---|
224743 | pGEMHE:mTREK-1 | In vitro transcription for Oocyte expression of mTREK-1 |
224744 | pGEMHE:mTREK-1(S131C) | In vitro transcription for Oocyte expression of mTREK-1(S131C) |
224745 | pGEMHE:mTREK-1(S131A) | In vitro transcription for Oocyte expression of mTREK-1(S131A) |
224746 | pGEMHE:mTREK-1(A286F) | In vitro transcription for Oocyte expression of mTREK-1(A286F) |
224747 | pGEMHE:mTREK-1(G171F) | In vitro transcription for Oocyte expression of mTREK-1(G171F) |
224748 | pGEMHE:mTREK-1(S131C/A286F) | In vitro transcription for Oocyte expression of mTREK-1(S131C/A286F) |
224749 | pGEMHE:mTREK-1(S131C/G171F) | In vitro transcription for Oocyte expression of mTREK-1(S131C/G171F) |
224750 | pGEMHE:mTREK-1(S131C/K271Q) | In vitro transcription for Oocyte expression of mTREK-1(S131C/K271Q) |
224751 | pGEMHE:mTREK-1 (C159A/C219A) | In vitro transcription for Oocyte expression of mTREK-1 (C159A/C219A) |
224752 | pGEMHE:mTREK-1 (S131C/C159A/C219A) | In vitro transcription for Oocyte expression of mTREK-1 (S131C/C159A/C219A) |
224753 | pGEMHE:mTREK-1 (S131A/C159A/C219A) | In vitro transcription for Oocyte expression of mTREK-1 (S131A/C159A/C219A) |
224754 | pGEMHE:mTREK-1 (C159A/C219A/C365A/C399A) | In vitro transcription for Oocyte expression of mTREK-1 (C159A/C219A/C365A/C399A) |
224755 | pGEMHE:mTREK-1 (S131C/C159A/C219A/C365A/C399A) | In vitro transcription for Oocyte expression of mTREK-1 (S131C/C159A/C219A/C365A/C399A) |
224756 | pGEMHE:mTREK-1 (S131A/C159A/C219A/C365A/C399A) | In vitro transcription for Oocyte expression of mTREK-1 (S131A/C159A/C219A/C365A/C399A) |
224758 | pGEMHE:mTREK-1(tandem S131C-wt) | In vitro transcription for Oocyte expression of mTREK-1(tandem S131C-wt) |
224759 | pGEMHE:mTREK-1(tandem wt-S131C) | In vitro transcription for Oocyte expression of mTREK-1(tandem wt-S131C) |
224760 | pGEMHE:mTREK-1(tandem S131C-S131C) | In vitro transcription for Oocyte expression of mTREK-1(tandem S131C-S131C) |
224761 | pGEMHE:hTRAAK | In vitro transcription for Oocyte expression of hTRAAK |
224762 | pGEMHE:hTRAAK(S118C) | In vitro transcription for Oocyte expression of hTRAAK(S118C) |
224763 | pGEMHE:hTRAAK(Q258K) | In vitro transcription for Oocyte expression of hTRAAK(Q258K) |
224764 | pGEMHE:hTRAAK(S118C/Q258K) | In vitro transcription for Oocyte expression of hTRAAK(S118C/Q258K) |
224765 | pGEMHE:mTRAAK | In vitro transcription for Oocyte expression of mTRAAK |
224766 | pGEMHE:mTRAAK(S93C) | In vitro transcription for Oocyte expression of mTRAAK(S93C) |
224767 | pGEMHE:mTRAAK(Q233K) | In vitro transcription for Oocyte expression of mTRAAK(Q233K) |
224768 | pGEMHE:mTRAAK(S93C/Q233K) | In vitro transcription for Oocyte expression of mTRAAK(S93C/Q233K) |
224769 | pcDNA3.1 TREK-2 | In vitro transcription for Oocyte expression of 1 TREK-2 |
224770 | pcDNA3.1 TREK-2(S156C) | In vitro transcription for Oocyte expression of 1 TREK-2(S156C) |
224772 | pcDNA3.1:mTRESK(S116C) | In vitro transcription for Oocyte expression of mTRESK(S116C) |
224773 | pIRES2-eGFP:HA-mTREK-1 | Mammalian expression vector for generating mouse TREK-1 |
224774 | pIRES2-eGFP:HA-mTREK-1(S131C) | Mammalian expression vector for generating mouse TREK-1 |
224775 | pIRES2-eGFP:HA-mTREK-1(S131C/A286F) | Mammalian expression vector for generating mouse TREK-1 |
224776 | pIRES2-eGFP:HA-mTREK-1(tandem wt-wt) | Mammalian expression vector for generating a tandem mTREK-1 with two identical monomers linked through a 20 AA flexible linker |
224777 | pIRES2-eGFP:HA-mTREK-1(tandem S131C-wt) | Mammalian expression vector for generating a tandem mTREK-1 with two identical monomers linked through a 20 AA flexible linker |
224778 | pIRES2-eGFP:HA-mTREK-1(tandem wt-S131C) | Mammalian expression vector for generating a tandem mTREK-1 with two identical monomers linked through a 20 AA flexible linker |
224779 | pIRES2-eGFP:HA-mTREK-1(tandem S131C-S131C) | Mammalian expression vector for generating a tandem mTREK-1 with two identical monomers linked through a 20 AA flexible linker |
224780 | pPICZ:K2P2.1(mTREK-1)Cryst S112C | Pichia pastoris expression vector for generating mouse TREK-1(21S-322T) + 3C cleavable site + eGFP + 10x His under the AOX1 promoter |
225490 | pCDNA3.1(+)-hSyn-HA-mTREK-1(S131C/A286F)-IRES-GFP | Neuronal expression IRES-containing bicistronic vector for generating mTREK-1 (S131C/A286F) + EGFP under the hSyn promoter. |