Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species.
Tabebordbar M, Lagerborg KA, Stanton A, King EM, Ye S, Tellez L, Krunnfusz A, Tavakoli S, Widrick JJ, Messemer KA, Troiano EC, Moghadaszadeh B, Peacker BL, Leacock KA, Horwitz N, Beggs AH, Wagers AJ, Sabeti PC
Cell. 2021 Sep 16;184(19):4919-4938.e22. doi: 10.1016/j.cell.2021.08.028. Epub 2021 Sep 9.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 224437 | kiCAP-AAV-MyoAAV1A | Rep/Cap plasmid for the production of MyoAAV 1A, a muscle-tropic AAV capsid in mice. |
| 224438 | kiCAP-AAV-MyoAAV1C | Rep/Cap plasmid for the production of MyoAAV 1C, a muscle-tropic AAV capsid in mice and macaques. |
| 224439 | kiCAP-AAV-MyoAAV1E | Rep/Cap plasmid for the production of MyoAAV 1E, a muscle-tropic AAV capsid in mice. |
| 224440 | kiCAP-AAV-MyoAAV2A | Rep/Cap plasmid for the production of MyoAAV 2A, a muscle-tropic AAV capsid in mice. |
| 224441 | kiCAP-AAV-MyoAAV2E | Rep/Cap plasmid for the production of MyoAAV 2E, a muscle-tropic AAV capsid in mice. |
| 224442 | kiCAP-AAV-MyoAAV3A | Rep/Cap plasmid for the production of MyoAAV 3A, a muscle-tropic AAV capsid in mice and macaques. |
| 224443 | kiCAP-AAV-MyoAAV3B | Rep/Cap plasmid for the production of MyoAAV 3B, a muscle-tropic AAV capsid in mice and macaques. |
| 224444 | kiCAP-AAV-MyoAAV3C | Rep/Cap plasmid for the production of MyoAAV 3C, a muscle-tropic AAV capsid in mice and macaques. |
| 224445 | kiCAP-AAV-MyoAAV3D | Rep/Cap plasmid for the production of MyoAAV 3D, a muscle-tropic AAV capsid in mice and macaques. |
| 224446 | kiCAP-AAV-MyoAAV3E | Rep/Cap plasmid for the production of MyoAAV 3E, a muscle-tropic AAV capsid in mice and macaques. |
| 224447 | kiCAP-AAV-MyoAAV3F | Rep/Cap plasmid for the production of MyoAAV 3F, a muscle-tropic AAV capsid in mice and macaques. |
| 224448 | kiCAP-AAV-MyoAAV4A | Rep/Cap plasmid for the production of MyoAAV 4A, a muscle-tropic AAV capsid in mice and macaques. |
| 224449 | kiCAP-AAV-MyoAAV4B | Rep/Cap plasmid for the production of MyoAAV 4B, a muscle-tropic AAV capsid in mice and macaques. |
| 224450 | kiCAP-AAV-MyoAAV4C | Rep/Cap plasmid for the production of MyoAAV 4C, a muscle-tropic AAV capsid in mice and macaques. |
| 224451 | kiCAP-AAV-MyoAAV4D | Rep/Cap plasmid for the production of MyoAAV 4D, a muscle-tropic AAV capsid in mice and macaques. |
| 224452 | kiCAP-AAV-MyoAAV4E | Rep/Cap plasmid for the production of MyoAAV 4E, a muscle-tropic AAV capsid in mice and macaques. |