Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM
Cell. 2024 Sep 6:S0092-8674(24)00908-5. doi: 10.1016/j.cell.2024.08.017.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 224261 | pProEx H-Ras(G12C) CL | Protein purification of H-Ras (G12C) |
| 224262 | pProEx N-Ras(G12C) CL | Protein purification of N-Ras (G12C) |
| 224263 | pProEx RalA(G23C) CL | Protein purification of RalA (G23C) |
| 224264 | pProEx Rap1A(G12C, L96F) CL | Protein purification of Rap1A (G12C, L96F) |
| 224265 | pProEx Ypt1(S17C) CL | Protein purification of Ypt1 (S17C) |
| 224266 | pProEx Rheb(R15C) CL | Protein purification of Rheb (R15C) |
| 224267 | pProEx Rit1(G47C) CL | Protein purification of Rit1 (G47C) |
| 224268 | pProEx M-Ras(G22C) CL | Protein purification of M-Ras (G22C) |
| 224269 | pProEx Rac1(G12C) CL | Protein purification of Rac1 (G12C) |
| 224270 | pProEx Rac1(G12C, K96H) CL | Protein purification of Rac1 (G12C, K96H) |
| 224271 | pProEx RhoA(G14C) CL | Protein purification of RhoA (G14C) |
| 224272 | pProEx Rab1A(S20C) CL | Protein purification of Rab1A (S20C) |
| 224273 | pProEx Rab5C(S30C) CL | Protein purification of Rab5C (S30C) |
| 224274 | pcDNA3.1(+) EGFP-RalA(WT) | Cell transfection and expression of RalA |
| 224275 | pcDNA3.1(+) EGFP-RalA(G23C) | cell transfection and expreswsion of RalA (G23C) |
| 224276 | pcDNA3.1(+) EGFP-Rap1A(WT) | Cell transfection and expression of Rap1A |
| 224277 | pcDNA3.1(+) EGFP-Rap1A(G12C, L96F) | Cell transfection and expression of Rap1A (G12C, L96F) |
| 224278 | pcDNA3.1(+) EGFP-Rac1(WT) | Cell transfection and expression of Rac1 |
| 224279 | pcDNA3.1(+) EGFP-Rac1(G12C) | Cell transfection and expression of Rac1 (G12C) |
| 224280 | pcDNA3.1(+) EGFP-Rac1(P29S) | Cell transfection and expression of Rac1 (P29S) |
| 224281 | pcDNA3.1(+) EGFP-Rac1(G12C, K96H) | Cell transfection and expression of Rac1 (G12C, K96H) |
| 224282 | pcDNA3.1(+) EGFP-Rac1(G12C, K96H, P29S) | Cell transfection and expression of Rac1 (G12C, K96H, P29S) |
| 224283 | pcDNA3.1(+) K-Ras(WT) | Cell transfection and expression of K-Ras |
| 224284 | pcDNA3.1(+) K-Ras(G12C) | Cell transfection and expression of K-Ras (G12C) |
| 224285 | pcDNA3.1(+) R-Ras1(WT) | Cell transfection and expression of R-Ras1 |
| 224286 | pcDNA3.1(+) R-Ras1(G38C) | Cell transfection and expression of R-Ras1 (G38C) |
| 224287 | pcDNA3.1(+) M-Ras(WT) | Cell transfection and expression of M-Ras |
| 224288 | pcDNA3.1(+) M-Ras(G22C) | Cell transfection and expression of M-Ras (G22C) |
| 224289 | pcDNA3.1(+) Rheb(WT) | Cell transfection and expression of Rheb |
| 224290 | pcDNA3.1(+) Rheb(R15C) | Cell transfection and expression of Rheb (R15C) |