PHD2 enzyme is an intracellular manganese sensor that initiates the homeostatic response against elevated manganese.

Gurol KC, Jursa T, Cho EJ, Fast W, Dalby KN, Smith DR, Mukhopadhyay S
Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2402538121. doi: 10.1073/pnas.2402538121. Epub 2024 Jun 21. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID	Plasmid	Purpose
223551	His-PHD2-181-426	His-tagged human PHD2 catalytic domain with TEV cleavage site between His and PHD2 for PHD2 purification
223552	pLJM1-PHD2	Lentivirus transfer plasmid for expression of full length human PHD2