Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, Chen P, Zhang H, Junqueira C, Amgalan D, Liang FG, Zhang J, Evavold CL, Hafner-Bratkovic I, Zhang Z, Fontana P, Xia S, Waldeck-Weiermair M, Pan Y, Michel T, Bar-Peled L, Wu H, Kagan JC, Kitsis RN, Zhang P, Liu X, Lieberman J
Immunity. 2023 Nov 14;56(11):2523-2541.e8. doi: 10.1016/j.immuni.2023.10.004. Epub 2023 Nov 3.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 223315 | pLenti-CMV-Puro-PNPT1 | Lentiviral vector expressing human PNPT1 |
| 223316 | pLenti-CMV-Puro-PNPT1 S484A | Lentiviral vector expressing human PNPT1 S484A variant |
| 234765 | lentiCRISPR v2-sgCrls1-1# | knockout Crls1 |
| 234766 | lentiCRISPR v2-sgCrls1-2# | knockout Crls |
| 234767 | lentiCRISPR v2-sgPlscr3-1# | knockout Plscr3 |
| 234769 | lentiCRISPR v2-sgPnpt1-1# | knockout Pnpt1 |
| 234770 | lentiCRISPR v2-sgPnpt1-2# | knockout Pnpt1 |
| 234771 | lentiCRISPRv2-sgCTL | Non Targeting Control |
| 234772 | lentiCRISPR v2-sgPlscr3-2# | knockout Plscr3 |