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Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.

Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, Chen P, Zhang H, Junqueira C, Amgalan D, Liang FG, Zhang J, Evavold CL, Hafner-Bratkovic I, Zhang Z, Fontana P, Xia S, Waldeck-Weiermair M, Pan Y, Michel T, Bar-Peled L, Wu H, Kagan JC, Kitsis RN, Zhang P, Liu X, Lieberman J
Immunity. 2023 Nov 14;56(11):2523-2541.e8. doi: 10.1016/j.immuni.2023.10.004. Epub 2023 Nov 3. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
223315pLenti-CMV-Puro-PNPT1Lentiviral vector expressing human PNPT1
223316pLenti-CMV-Puro-PNPT1 S484ALentiviral vector expressing human PNPT1 S484A variant

Antibodies from Article