Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs.
Reddy NR, Maachi H, Xiao Y, Simic MS, Yu W, Tonai Y, Cabanillas DA, Serrano-Wu E, Pauerstein PT, Tamaki W, Allen GM, Parent AV, Hebrok M, Lim WA
Science. 2024 Dec 6;386(6726):eadl4793. doi: 10.1126/science.adl4793. Epub 2024 Dec 6.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 223208 | pHR-GAL4-PDL1-IRES-mCherry-PGK-BFP | Lentiviral vector - mCherry reporter and PDL1 for Gal4DBDVP64 synNotch receptors with a constitutive BFP |
| 223209 | pHR-GAL4-IL10-IRES-mCherry-PGK-BFP | Lentiviral vector - mCherry reporter and IL10 for Gal4DBDVP64 synNotch receptors with a constitutive BFP |
| 223210 | pHR-GAL4-IL35-IRES-mCherry-PGK-BFP | Lentiviral vector - mCherry reporter and IL35 for Gal4DBDVP64 synNotch receptors with a constitutive BFP |
| 223213 | pHR-GAL4-UAS-activemTGFb1-IRES-mCherry-PGK-BFP | Lentiviral vector - mCherry reporter and TGFb1 for Gal4DBDVP64 synNotch receptors with a constitutive BFP |
| 223214 | pHR-GAL4-UAS—sTNFaR-IRES-mCherry-PGK-BFP | Lentiviral vector - mCherry reporter and sTNFaR for Gal4DBDVP64 synNotch receptors with a constitutive BFP |
| 223215 | pHR- GAL4-UAS-BAMH1-IRES-mCherry-PGK-BFP | Lentiviral vector - mCherry reporter with a BAMH1 site for Gal4DBDVP64 synNotch receptors with a constitutive BFP |