The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer.
Adam S, Rossi SE, Moatti N, De Marco Zompit M, Xue Y, Ng TF, Alvarez-Quilon A, Desjardins J, Bhaskaran V, Martino G, Setiaputra D, Noordermeer SM, Ohsumi TK, Hustedt N, Szilard RK, Chaudhary N, Munro M, Veloso A, Melo H, Yin SY, Papp R, Young JTF, Zinda M, Stucki M, Durocher D
Nat Cancer. 2021 Dec;2(12):1357-1371. doi: 10.1038/s43018-021-00266-w. Epub 2021 Nov 11.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 222623 | pcDNA5-FRT/T0-Flag-CIP2A | mammalian expression vector of Flag-tagged CIP2A |
| 222624 | pHIV-NAT-FLAG-CIP2A FL (sg2R) | Lentiviral vector that expresses Flag-tagged sgRNA resistant CIP2A in mammalian cells |
| 222625 | pHIV-NAT-FLAG-CIP2A ∆NES (del561-625) | Lentiviral vector that expresses Flag-tagged CIP2A NES mutant in mammalian cells |