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Ligand binding initiates single-molecule integrin conformational activation.

Li J, Jo MH, Yan J, Hall T, Lee J, Lopez-Sanchez U, Yan S, Ha T, Springer TA
Cell. 2024 May 14:S0092-8674(24)00475-6. doi: 10.1016/j.cell.2024.04.049. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
221394PD2529 human alpha5 ectoMammalian expression of human integrin alpha5 ectodomain
221395PD2529 human alpha5 fullMammalian expression of human integrin alpha5 full length
221396pcDNA3.4 human alpha5 fullMammalian expression of human integrin alpha5 full length
221397pcDNA3.4 human alpha4 fullMammalian expression of human integrin alpha4 full length
221398PD2529 human beta1 ectoMammalian expression of human integrin beta1 ectodomain
221399Beta1 Q280* K418* ectodomainMammalian expression of human integrin beta1 Q280* K418* ectodomain
221400Beta1 N391* N562* ectodomainMammalian expression of human integrin beta1 N391* N562* ectodomain
221401PD2529 human beta1 fullMammalian expression of human integrin beta1 full-length
221402Beta1 Q280* full-lengthMammalian expression of human integrin beta1 Q280* full-length
221403Beta1 K418* full-lengthMammalian expression of human integrin beta1 K418* full-length
221404Beta1 N391* full-lengthMammalian expression of human integrin beta1 N391* full-length
221405Beta1 N562* full-lengthMammalian expression of human integrin beta1 N562* full-length
221406Beta1 Q280* K418* full-lengthMammalian expression of human integrin beta1 Q280* K418* full-length
221407Beta1 N391* N562* full-lengthMammalian expression of human integrin beta1 N391* N562* full-length
221408Talin1 head EGFP fusionMammalian expression of Talin1 head EGFP fusion for mammalian expression

Antibodies from Article