Ligand binding initiates single-molecule integrin conformational activation.

Li J, Jo MH, Yan J, Hall T, Lee J, Lopez-Sanchez U, Yan S, Ha T, Springer TA
Cell. 2024 May 14:S0092-8674(24)00475-6. doi: 10.1016/j.cell.2024.04.049. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

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ID	Plasmid	Purpose
221408	Talin1 head EGFP fusion	Mammalian expression of Talin1 head EGFP fusion for mammalian expression
221407	Beta1 N391* N562* full-length	Mammalian expression of human integrin beta1 N391* N562* full-length
221406	Beta1 Q280* K418* full-length	Mammalian expression of human integrin beta1 Q280* K418* full-length
221405	Beta1 N562* full-length	Mammalian expression of human integrin beta1 N562* full-length
221404	Beta1 N391* full-length	Mammalian expression of human integrin beta1 N391* full-length
221403	Beta1 K418* full-length	Mammalian expression of human integrin beta1 K418* full-length
221402	Beta1 Q280* full-length	Mammalian expression of human integrin beta1 Q280* full-length
221401	PD2529 human beta1 full	Mammalian expression of human integrin beta1 full-length
221400	Beta1 N391* N562* ectodomain	Mammalian expression of human integrin beta1 N391* N562* ectodomain
221399	Beta1 Q280* K418* ectodomain	Mammalian expression of human integrin beta1 Q280* K418* ectodomain