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Phosphoglycerate kinase is a central leverage point in Parkinson's disease-driven neuronal metabolic deficits.

Kokotos AC, Antoniazzi AM, Unda SR, Ko MS, Park D, Eliezer D, Kaplitt MG, De Camilli P, Ryan TA
Sci Adv. 2024 Aug 23;10(34):eadn6016. doi: 10.1126/sciadv.adn6016. Epub 2024 Aug 21. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
191566pLKO.1 - TRC mTagBFP2Expresses an shRNA and mTagBFP2
191567pLKO.1 - TRC mTagBFP2-Synapsin1aExpresses an shRNA and mTagBFP2-synapsin1a
220910plenti hSyn PGK1-HALONeuronal specific expression of the fusion construct PGK1-HALO
220911AAV hSyn hPGK1-mRubyNeuronal specific expression of the fusion construct PGK1-mRuby
220912AAV hSyn mRubyNeuronal specific expression of mRuby
220913CMV PGK1-3xHAExpresses PGK1-3xHA
220914CMV DJ-1 C106AExpresses DJ-1 with the C106A mutation
220915plenti hSyn HK1Neuronal specific expression of HK1
220916plenti hSyn AldoANeuronal specific expression of AldoA
220917plenti hSyn AldoCNeuronal specific expression of AldoC
220918plenti hSyn GAPDHNeuronal specific expression of GAPDH
220919plenti hSyn PGK1Neuronal specific expression of PGK1
220920plenti hSyn PKM1Neuronal specific expression of PKM1
222869pLKO.1 mTagBFP2 rat PGK1 shRNAExpresses mTagBFP2 along with an shRNA against rat PGK1
222870pLKO.1 mTagBFP2 rat DJ-1 shRNAExpresses mTagBFP2 along with an shRNA against rat DJ-1

Antibodies from Article