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HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.

Blakely WJ, Hatterschide J, White EA
mBio. 2024 Sep 9:e0181124. doi: 10.1128/mbio.01811-24. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
221643p8221 pLIX-PTPN14Doxycycline-inducible overexpression of human WT PTPN14
221644p8224 pLIX-PTPN14 ΔPPXY1/2Doxycycline-inducible overexpression of human PTPN14 ΔPPXY1/2 mutant
221645p8552 pLIX-PTPN14 ΔPPXY3/4Doxycycline-inducible overexpression of human PTPN14 ΔPPXY3/4 mutant
221646p8215 pHAGE N-V5 PTPN14 ΔPPXY1/2Constitutive ectopic expression of human PTPN14 ΔPPXY1/2 mutant
221647p8180 pHAGE N-V5 PTPN14 ΔPPXY3/4Constitutive ectopic expression of human PTPN14 ΔPPXY3/4 mutant
221648p8189 pHAGE N-V5 PTPN14 C1121SConstitutive ectopic expression of human PTPN14 C1121S mutant
221649p8389 LentiCRISPRv2 Neo sgNT-1Expression of non-targeting control sgRNA
221650p8390 LentiCRISPRv2 Neo sgNT-2Expression of non-targeting control sgRNA
221651p8391 LentiCRISPRv2 Neo sgPTPN14-1Expression of sgRNA targeting the locus of human PTPN14
221652p8392 LentiCRISPRv2 Neo sgPTPN14-3Expression of sgRNA targeting the locus of human PTPN14

Antibodies from Article