Engineering APOBEC3A deaminase for highly accurate and efficient base editing.
Yang L, Huo Y, Wang M, Zhang D, Zhang T, Wu H, Rao X, Meng H, Yin S, Mei J, Zhang D, Chen X, Lv J, Liu M, Cheng Y, Guan Y, Feng B, Song G, Yi C, Liu M, Zeng F, Wang L, Li D
Nat Chem Biol. 2024 Mar 29. doi: 10.1038/s41589-024-01595-4.
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 220892 | pCMV-haA3A-CBE-A | Express haA3A-CBE-A (with SpCas9) in mammalian cells |
| 220893 | pCMV-haA3A-CBE-VA | Express haA3A-CBE-VA (with SpCas9) in mammalian cells |
| 220894 | pCMV-haA3A-CBE-G | Express haA3A-CBE-G (with SpCas9) in mammalian cells |
| 220895 | pCMV-haA3A-CBE-A-NG | Express haA3A-CBE-A-NG (with SpCas9-NG variant) in mammalian cells |
| 220896 | pCMV-haA3A-CBE-VA-NG | Express haA3A-CBE-VA-NG (with SpCas9-NG variant) in mammalian cells |
| 220897 | pCMV-haA3A-CBE-G-NG | Express haA3A-CBE-G-NG (with SpCas9-NG variant) in mammalian cells |
| 220898 | AAV-haA3A-CBE-G-N | AAV genome encoding the N-terminal of haA3A-CBE-G |
| 220899 | AAV-haA3A-CBE-G-C | AAV genome encoding the C-terminal of haA3A-CBE-G, and sgRNA |