Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition.
Libe-Philippot B, Iwata R, Recupero AJ, Wierda K, Bernal Garcia S, Hammond L, van Benthem A, Limame R, Ditkowska M, Beckers S, Gaspariunaite V, Peze-Heidsieck E, Remans D, Charrier C, Theys T, Polleux F, Vanderhaeghen P
Neuron. 2024 Oct 9:S0896-6273(24)00645-7. doi: 10.1016/j.neuron.2024.08.021.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 220795 | pLV-H1-shScramble-hsynapsin-EGFP | control shRNA plasmid with EGFP expression in neurons |
| 220796 | pLV-H1-shSRGAP2B/C#1-hsynapsin-EGFP | shRNA plasmid against human SRGAP2B/C genes (#1) with EGFP expression in neurons |
| 220797 | pLV-H1-shSRGAP2B/C#2-hsynapsin-EGFP | shRNA plasmid against human SRGAP2B/C genes (#2) with EGFP expression in neurons |
| 220798 | pLV-H1-shSRGAP2A-hsynapsin-EGFP | shRNA plasmid against human SRGAP2A gene with EGFP expression in neurons |