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Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer's pathology.

Kumar P, Goettemoeller AM, Espinosa-Garcia C, Tobin BR, Tfaily A, Nelson RS, Natu A, Dammer EB, Santiago JV, Malepati S, Cheng L, Xiao H, Duong DD, Seyfried NT, Wood LB, Rowan MJM, Rangaraju S
Nat Commun. 2024 Apr 1;15(1):2823. doi: 10.1038/s41467-024-47028-7. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
220310pAAV.E2.ChETADirects ChETA optogenetic actuator to fast spiking interneurons in cortex. Allows for single APs to be evoked.

Antibodies from Article