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Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN

Wang J, Heinz M, Han K, Shah VJ, Hasselbeck S, Schwalm MP, Rathore R, Hummer G, Zhou J, Dikic I, Cheng X
Cell Reports Physical Science, Volume 5, Issue 5, 101960 (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
220292GFP-Bcl-2-K17Rmammalian expression of Bcl-2-K17R tagged with GFP
220293GFP-Bcl-2-K22Rmammalian expression of Bcl-2-K22R tagged with GFP
220294GFP-Bcl-2-K17R-K22Rmammalian expression of Bcl-2-K17R-K22R tagged with GFP
220295GFP-Bcl-2-G101Vmammalian expression of Bcl-2-G101V tagged with GFP
220296GFP-Bcl-2-F104Cmammalian expression of Bcl-2-F104C tagged with GFP
220297GFP-Bcl-2-ΔBH1mammalian expression of Bcl-2-ΔBH1 tagged with GFP
220298GFP-Bcl-2-ΔBH2mammalian expression of Bcl-2-ΔBH2 tagged with GFP
220299GFP-Bcl-2-ΔBH3mammalian expression of Bcl-2-ΔBH3 tagged with GFP
220300GFP-Bcl-2-ΔBH4mammalian expression of Bcl-2-ΔBH4 tagged with GFP
220301GFP-Bcl-2-G128Lmammalian expression of Bcl-2-G128L tagged with GFP
220302GFP-Bcl-2-A131Lmammalian expression of Bcl-2-A131L tagged with GFP
220303GFP-Bcl-2-T132Lmammalian expression of Bcl-2-T132L tagged with GFP
220304GFP-Bcl-2-G128L-A131L-T132Lmammalian expression of Bcl-2-G128L-A131L-T132L tagged with GFP

Antibodies from Article