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In vivo selection in non-human primates identifies AAV capsids for on-target CSF delivery to spinal cord

Hanlon KS, Cheng M, Ferrer M, Ryu JR, Lee B, De La Cruz D, Patel N, Espinoza P, Santoscoy MC, Gong Y, Ng C, Nguyen DM, Nammour J, Clark SQ, Heine VM, Sun W, Kozarsky K, Maguire CA
Molecular Therapy. 2024 Jun 5. doi.org/10.1016/j.ymthe.2024.05.040 (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
218403TR2Expresses TR2 peptide in AAV9 capsid
218404NL1NL1 insert in AAV9 capsid
218405TH1TH1 insert in AAV9 capsid
218406TP1TP1 insert in AAV9 capsid

Antibodies from Article