Engineered extrachromosomal oncogene amplifications promote tumorigenesis
Pradella D, Zhang M, Gao R, Yao MA, Gluchowska KM, Cendon-Florez Y, Mishra T, La Rocca G, Weigl M, Jiao Z, Nguyen HHM, Lisi M, Ozimek MM, Mastroleo C, Chen K, Grimm F, Luebeck J, Zhang S, Zolli AA, Sun EG, Dameracharla B, Zhao Z, Pritykin Y, Sigel C, Chang HY, Mischel PS, Bafna V, Antonescu CR, Ventura A
Nature (2024)
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 219563 | 5` CC: Puro – loxP – GFP-C | 5` circularization cassette.Used in combination with one of the 3' circularization cassettes to induce Cre-mediated circularizazion or inversion of a desired genomic region. |
| 219564 | 3` CC: Hygro – GFP-N – loxP – mScarlet | 3` circularization cassette.To induce Cre-mediated circularization or inversion of a genomic region with concomitant GFP reconstitution and mScarlet expression from the chromosome |
| 219565 | 3` CC: Hygro – H2B-GFP-N – loxP – mScarlet | 3` circularization cassette to induce Cre-mediated circularization of a genomic region flanked by loxP sites with H2B-GFP reconstitution and mScarlet expression from the chromosome |