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PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer.

Nikolatou K, Sandilands E, Roman-Fernandez A, Cumming EM, Freckmann E, Lilla S, Buetow L, McGarry L, Neilson M, Shaw R, Strachan D, Miller C, Huang DT, McNeish IA, Norman JC, Zanivan S, Bryant DM
EMBO J. 2023 Sep 18;42(18):e113987. doi: 10.15252/embj.2023113987. Epub 2023 Aug 14. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
233244pLentiCRISPR V2 Neo sgNon-targetingKnock out - non targeting control
233245pLentiCRISPR V2 Neo PTEN sgRNA2Knock out of murine PTEN
233246pLentiCRISPR V2 Neo PTEN sgRNA5Knock out of murine PTEN
233247pLentiCRISPR V2 Neo sgAGAP1_2Knock out of murine AGAP1
233248pLentiCRISPR V2 Neo sgAGAP1_3Knock out of murine AGAP1
233249pLentiCRISPR V2 Neo sgITGB1_2Knock out of murine ITGB1
233250pLentiCRISPR V2 Neo sgITGB1_3Knock out of murine ITGB1
233251pLentiCRISPR V2 Neo sgITGA5_1Knock out of murine ITGA5
233252pLentiCRISPR V2 Neo sgITGA5_4Knock out of murine ITGA5
233253pLentiCRISPR V2 Neo sgITGA5_5Knock out of murine ITGA5
233256hARF6-R WT TurboID V5 T2A BFPExpression of BFP-tagged ARF6 WT for Turbo ID experiments
233257Start Stuffer TurboID V5 T2A BFPExpression of BFP-tagged vector for Turbo ID experiments
233261mNG-PH-CYTH3-2G Expression of mNeonGreen-tagged PIP3 reporter

Antibodies from Article