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Broad range plastid genome editing with monomeric TALE-linked cytosine and dual base editors.

Wang X, Fang T, Lu J, Tripathi L, Qi Y
Plant Biotechnol J. 2024 May 6. doi: 10.1111/pbi.14358. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
218171pYPQ121-Split-TALEDExpress plastid TALE-linked deaminases (TALED), composed of TALE, split DddA originated from Burkholderia cenocepacia, and an engineered deoxyadenosine deaminase derived from the E. coli TadA protein
218172pYPQ121-mTCBEExpress plastid monomeric TALE-linked CBE, composed of TALE, a catalytically impaired, full length DddA variant (E1347A), a human APOBEC3A variant (hA3A-Y130F), and UGI
218173pYPQ121-mTCABE-TExpress plastid monomeric TALE-linked CABE-T, composed of TALE, a catalytically impaired, full length DddA variant (E1347A), a TadA-derived deaminase, and UGI
218174PYPQ121-DdCBEExpress plastid DdCBE, composed of TALE, split DddA originated from Burkholderia cenocepacia and UGIs

Antibodies from Article