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The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling.

Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E
Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
217615Human USP46Mammalian expression of USP46
217618Human FLAG-WDR20Mammalian expression of FLAG tagged WDR20
217619Human FLAG-UAF1 S170YMammalian expression of FLAG tagged mutant (UAF1 S170Y) UAF1

Antibodies from Article