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The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.

Spencer ZT, Ng VH, Benchabane H, Siddiqui GS, Duwadi D, Maines B, Bryant JM, Schwarzkopf A, Yuan K, Kassel SN, Mishra A, Pimentel A, Lebensohn AM, Rohatgi R, Gerber SA, Robbins DJ, Lee E, Ahmed Y
Nat Commun. 2023 Oct 5;14(1):6174. doi: 10.1038/s41467-023-41843-0. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
217620Drosophila Usp46-V5 Mammalian expression of V5 tagged Drosophila Usp46
217622Drosophila Wdr20-V5 Mammalian expression of V5 tagged Drosophila Wdr20

Antibodies from Article