In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury.
Guo CT, Jardin BD, Lin JS, Ambroise RL, Wang Z, Yang LZ, Mazumdar N, Lu FJ, Ma Q, Cao YP, Liu CZ, Li KL, Liu XJ, Lan F, Zhao MM, Xiao H, Dong ED, Pu WT, Guo YX
Acta Pharmacol Sin. 2024 Jul 23. doi: 10.1038/s41401-024-01348-y.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 216830 | AAV-U6-PALMDgRNA1+2-cTnT-Cre -mi122TS | cardiomyocytes-specific plasmid, expressing gRNAs targeting Palmd exon7, containing a mi122TS sequence to decrease off-target effects in the liver. |
| 216831 | pENAAV-cTNT-actn2-BioID2-HA | cardiomyocytes-specific plasmid, expressing the coding sequence of mouse Actn2, biotin ligase BioID2, and a HA tag. |
| 216832 | pAAV-cTNT-GFP-Palmd | cardiomyocytes-specific plasmid, expressing Gfp and the coding sequence of mouse Palmd |
| 216833 | pCMV-3*HA-Palmd | expressing HA tag and the coding sequence of mouse Palmd |
| 216834 | pCMV-3*flag-NEXN | expressing Falg tag and the coding sequence of mouse Nexn |
| 216835 | pAAV-cTNT-NEXN-GFP | cardiomyocytes-specific plasmid, expressing the coding sequence of mouse Nexn and GFP tag |