Integration of zeta-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells.
Kath J, Franke C, Drosdek V, Du W, Glaser V, Fuster-Garcia C, Stein M, Zittel T, Schulenberg S, Porter CE, Andersch L, Kunkele A, Alcaniz J, Hoffmann J, Abken H, Abou-El-Enein M, Pruss A, Suzuki M, Cathomen T, Stripecke R, Volk HD, Reinke P, Schmueck-Henneresse M, Wagner DL
Blood. 2024 Mar 17:blood.2023020973. doi: 10.1182/blood.2023020973.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 215758 | pUC19-HDRT-CD3z-truncCAR(anti-CD19) | HDR template to insert a truncated CD3-zeta-deficient CD19-CAR into CD247 exon 2 |
| 215759 | pUC19-HDRT-CD3z-truncCARgsg(anti-CD19) | HDR template to insert a truncated CD3-zeta-deficient CD19-CAR into CD247 exon 2 (enhanced expression by GSG-2A linker) |