Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes.
Sun Y, Young MC, Woodward CH, Danon JN, Truong HV, Gupta S, Winters TJ, Font-Burgada J, Burslem GM, Sgourakis NG
Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2304055120. doi: 10.1073/pnas.2304055120. Epub 2023 Jun 13.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 215569 | OPEN HLA-A*02:01-BirA | E. coli expression of BirA tagged HLA-A*02:01 containing a cysteine mutation for disulfide linkage to mutant beta-2 microglobulin. |
| 215657 | OPEN Beta2-microglobulin | E. coli expression of human beta-2-microglobulin containing a cysteine mutation for disulfide linkage to mutant HLA. |