The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases.
Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M, Jonatova L, Cernohorsky NH, Zieba JT, Kostas M, Haugsten EM, Wesche J, Erneux C, Trantirek L, Krakow D, Krejci P
Sci Signal. 2018 Sep 18;11(548):eaap8608. doi: 10.1126/scisignal.aap8608. PubMed Article
Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M, Jonatova L, Cernohorsky NH, Zieba JT, Kostas M, Haugsten EM, Wesche J, Erneux C, Trantirek L, Krakow D, Krejci P
Sci Signal. 2018 Sep 18;11(548):eaap8608. doi: 10.1126/scisignal.aap8608. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 214901 | SHIP2-ΔPS | expression of the truncated variants of the SHIP2 without phosphatase domain |
| 214902 | SHIP2-ΔPR1 | expression of the truncated variants of the SHIP2 without first proline-rich domain |
| 214903 | SHIP2-N1 | expression of the truncated variants of the SHIP2 that retains only SH2 domain and first proline-rich domain |
| 214904 | SHIP2-N2 | expression of the truncated variants of the SHIP2 that retains first proline-rich domain |
| 214905 | SHIP2-C1 | expression of the truncated variants of the SHIP2 that retains second proline-rich domain and C-terminal sterile alpha motif |
| 214906 | SHIP2-C2 | expression of the truncated variants of the SHIP2 that retains second proline-rich domain |
| 214907 | SHIP2-WT | expression of the full length variants of the SHIP2 |