The integrated stress response drives MET oncogene overexpression in cancers.
Cerqua M, Foiani M, Boccaccio C, Comoglio PM, Altintas DM
EMBO J. 2025 Jan 7. doi: 10.1038/s44318-024-00338-4.
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 214103 | pLenti_5'UTR_MET_GFP | MET 5'UTR upstream of mGFP |
| 214104 | pLenti-uORF1-MET | MET 5'UTR upstream of mGFP (uORF1 mutated) |
| 214105 | pLenti-uORF2-MET | MET 5'UTR upstream of mGFP (uORF2 mutated) |
| 214106 | pLenti-uORF1,2-MET | MET 5'UTR upstream of mGFP (uORF1 and uORF2 mutated) |
| 216535 | pLenti-Exon1-MET | MET CDS with 5'UTR |
| 216536 | pLenti-Exon2-MET | MET CDS without 5'UTR |
| 216537 | pU6-sgRNA_MET_uORF1 | gRNA and template for MET 5'UTR uORF1 mutation |
| 216538 | pU6-sgRNA_MET_uORF2 | gRNA and template for MET 5'UTR uORF2 mutation |
| 226458 | pGL4.23[METUTRwt/luc2/minP] | wt MET 5'UTR upstream FLuc |
| 226459 | pGL4.23[uORF1/luc2/minP] | MET 5'UTR (uORF1 mutated) upstream FLuc |
| 226460 | pGL4.23[uORF2/luc2/minP] | MET 5'UTR (uORF2 mutated) upstream FLuc |
| 226461 | pGL4.23[uORF1,2/luc2/minP] | MET 5'UTR (uORF1 and uORF2 mutated) upstream FLuc |
| 226462 | RLuc_IRES_FLuc_Pless | Promoterless bicistronic luciferase |
| 226463 | RLuc_MET_95_FLuc | MET predicted IRES between Rluc and Fluc |
| 226464 | RLuc_MET_95_FLuc_Pless | Promoterless MET predicted IRES between Rluc and Fluc |