Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency.
Root J, Mendsaikhan A, Taylor G, Merino P, Nandy S, Wang M, Araujo LT, Ryu D, Holler C, Thompson BM, Astarita G, Blain JF, Kukar T
Cell Rep. 2024 Nov 19;43(12):114985. doi: 10.1016/j.celrep.2024.114985.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 213682 | pAAV hPGRN | Expresses human progranulin (PGRN) with an N-terminal twin-Strep-V5 tag |
| 213683 | pAAV hGRN2 | Expresses human granulin-2 with an N-terminal twin-Strep-FLAG tag |
| 213684 | pAAV hGRN4 | Expresses human granulin-4 with an N-terminal twin-Strep-FLAG tag |
| 213685 | pAAV GFP | Expresses Green Fluorescent Protein (GFP) with an N-terminal twin-Strep tag |