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Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer.

Klomp JE, Diehl JN, Klomp JA, Edwards AC, Yang R, Morales AJ, Taylor KE, Drizyte-Miller K, Bryant KL, Schaefer A, Johnson JL, Huntsman EM, Yaron TM, Pierobon M, Baldelli E, Prevatte AW, Barker NK, Herring LE, Petricoin EF 3rd, Graves LM, Cantley LC, Cox AD, Der CJ, Stalnecker CA
Science. 2024 Jun 7;384(6700):eadk0850. doi: 10.1126/science.adk0850. Epub 2024 Jun 7. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
213591pInducer-myc-ERK1-R84SDoxycycline inducible expression of myc-tagged ERK1-R84S cDNA in mammilian cells
213592pInducer-myc-ERK1-S170DDoxycycline inducible expression of myc-tagged ERK1-S170D cDNA in mammilian cells
213593pInducer-myc-ERK1-R84S/S170DDoxycycline inducible expression of myc-tagged ERK1-R84S/S170D cDNA in mammilian cells
213594pInducer-myc-ERK1-R84S/D338NDoxycycline inducible expression of myc-tagged ERK1-R84S/D338N cDNA in mammilian cells
213595pInducer-myc-ERK1-R84S/S170D/D338NDoxycycline inducible expression of myc-tagged ERK1-R84S/S170D/D338N cDNA in mammilian cells
213596pInducer-myc-ERK1-R84S/S170D/Y280ADoxycycline inducible expression of myc-tagged ERK1-R84S/S170D/Y280A cDNA in mammilian cells
213597pInducer-myc-ERK2-R67S/S153DDoxycycline inducible expression of myc-tagged ERK2-R67S/S153D cDNA in mammilian cells
213598pInducer-myc-ERK2-R67S/S153D/D321NDoxycycline inducible expression of myc-tagged ERK2-R67S/S153D/D321N cDNA in mammilian cells
213599pInducer-myc-ERK2-R67S/S153D/Y263ADoxycycline inducible expression of myc-tagged ERK2-R67S/S153D/Y263A cDNA in mammilian cells

Antibodies from Article