Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase.
Meyer C, Garzia A, Miller MW, Huggins DJ, Myers RW, Hoffmann HH, Ashbrook AW, Jannath SY, Liverton N, Kargman S, Zimmerman M, Nelson AM, Sharma V, Dolgov E, Cangialosi J, Penalva-Lopez S, Alvarez N, Chang CW, Oswal N, Gonzalez I, Rasheed R, Goldgirsh K, Davis JA, Ramos-Espiritu L, Menezes MR, Larson C, Nitsche J, Ganichkin O, Alwaseem H, Molina H, Steinbacher S, Glickman JF, Perlin DS, Rice CM, Meinke PT, Tuschl T
Nature. 2024 Dec 11. doi: 10.1038/s41586-024-08320-0.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 213518 | pRSF_his6_sumo_SARS_CoV2_NSP14 | Expresses NSP14 of SARS-CoV-2 |
| 213519 | pRSF_his6_sumo_OC43_NSP14 | Expresses NSP14 of hCoV OC43 |
| 213520 | pRSF_his6_sumo_NL63_NSP14 | Expresses NSP14 of hCoV NL63 |
| 213521 | pRSF_his6_sumo_229E_NSP14 | Expresses NSP14 of hCoV 229E |
| 213522 | pRSF_his6_sumo_SARS_CoV2_NSP14_V290A | Expresses NSP14 of SARS-CoV-2 with a single point mutation V290A |
| 213523 | pRSF_his6_sumo_SARS_CoV2_NSP14_N306K | Expresses NSP14 of SARS-CoV-2 with a single point mutation N306K |
| 213524 | pRSF_his6_sumo_SARS_CoV2_NSP14_P335S | Expresses NSP14 of SARS-CoV-2 with a single point mutation P335S |
| 213525 | pRSF_his6_sumo_SARS_CoV2_NSP14_P335H | Expresses NSP14 of SARS-CoV-2 with a single point mutation P335H |
| 213526 | pRSF_his6_sumo_SARS_CoV2_NSP14_H424R | Expresses NSP14 of SARS-CoV-2 with a single point mutation H424R |
| 213527 | pRSF_his6_sumo_SARS_CoV2_NSP14_D90A/E92A | Expresses NSP14 of SARS-CoV-2 with two point mutations D90A and E92A |
| 213528 | pRSF_his6_sumo_hRNMT_RAM | Expresses the human RNMT-RAM complex |
| 213529 | pRSF_his6_sumo_ZIKV_NS5_MTase | Expresses the MTase domain of NS5 of ZIKV |