SAM-DNMT3A, a strategy for induction of genome-wide DNA methylation, identifies DNA methylation as a vulnerability in ER-positive breast cancers.
Hosseinpour M, Xi X, Liu L, Malaver-Ortega L, Perlaza-Jimenez L, Joo JE, York HM, Beesley J, Caldon CE, Dugue PA, Dowty JG, Arumugam S, Southey MC, Rosenbluh J
Nat Commun. 2024 Dec 1;15(1):10449. doi: 10.1038/s41467-024-54824-8.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 213164 | SAM-DNMT3A empty | Empty vector (no sgRNA) for induction of global DNA methylation. |
| 213165 | SAM-DNMT3A+sgGFP | Vector with sgGFP for induction of global DNA methylation. |
| 213166 | SAM-DNMT3A+sgAAVS1_145 | Vector with sgAAVS1 for induction of global DNA methylation. |
| 213167 | SAM-DNMT3A+sgAAVS1_118 | Vector with sgAAVS1 for induction of global DNA methylation. |
| 213168 | SAM-DNMT3A-inactiveEmpty | Empty Vector (no sgRNA) used as a negative control (inactive DNMT3A) for induction of global DNA methylation. |
| 213169 | SAM-DNMT3A-inactive+sgGFP | Vector with sgGFP used as a negative control (inactive DNMT3A) for induction of global DNA methylation. |
| 213170 | SAM-DNMT3A-inactive+sgAAVS1_145 | Vector with sgAAVS1 used as a negative control (inactive DNMT3A) for induction of global DNA methylation. |
| 213171 | SAM-DNMT3A-inactive+sgAAVS1_118 | Vector with sgAAVS1 used as a negative control (inactive DNMT3A) for induction of global DNA methylation. |