Engineering a transposon-associated TnpB-omegaRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model.
Li Z, Guo R, Sun X, Li G, Shao Z, Huo X, Yang R, Liu X, Cao X, Zhang H, Zhang W, Zhang X, Ma S, Zhang M, Liu Y, Yao Y, Shi J, Yang H, Hu C, Zhou Y, Xu C
Nat Commun. 2024 Jan 27;15(1):831. doi: 10.1038/s41467-024-45197-z.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 212967 | ISDra2-TnpB-mCherry-U6-ωRNA* | Expression vector for expression of ISDra2-TnpB driven by chicken β-actin promoter and mCherry driven by CMV promoter |
| 212968 | AAV_U6-ωRNA*_ISDra2-TnpB-mNG | AAV vector for encoding an ISDra2-TnpB driven by EFs promoter |