Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.

Bashore FM, Katis VL, Du Y, Sikdar A, Wang D, Bradshaw WJ, Rygiel KA, Leisner TM, Chalk R, Mishra S, Williams AC, Gileadi O, Brennan PE, Wiley JC, Gockley J, Cary GA, Carter GW, Young JE, Pearce KH, Fu H, Axtman AD
bioRxiv. 2023 Jul 29:2023.07.28.551026. doi: 10.1101/2023.07.28.551026. Preprint. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
175489	SYKA-c020	Protein expression in bacterial cells. Tandem SH2 domains, M6-N269. Can be used for crystallography.
175490	SYKA-c022	Protein expression in bacterial cells. Tandem SH2 domains, M6-N269. Can be biotinylated.