Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability.

Derry JJ, Richard S, Valderrama Carvajal H, Ye X, Vasioukhin V, Cochrane AW, Chen T, Tyner AL
Mol Cell Biol. 2000 Aug;20(16):6114-26. doi: 10.1128/MCB.20.16.6114-6126.2000. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
210722	pBabe-Sik-WT	Construct for stable expression of mouse wild type Ptk6 (Sik) in mammalian cells.
210723	pBabe-Sik-YF	Construct for stable expression of constitutively active mouse Ptk6 (Sik) in mammalian cells.