Developing mitochondrial base editors with diverse context compatibility and high fidelity via saturated spacer library.
Sun H, Wang Z, Shen L, Feng Y, Han L, Qian X, Meng R, Ji K, Liang D, Zhou F, Lou X, Zhang J, Shen B
Nat Commun. 2023 Oct 19;14(1):6625. doi: 10.1038/s41467-023-42359-3. PubMed Article
Sun H, Wang Z, Shen L, Feng Y, Han L, Qian X, Meng R, Ji K, Liang D, Zhou F, Lou X, Zhang J, Shen B
Nat Commun. 2023 Oct 19;14(1):6625. doi: 10.1038/s41467-023-42359-3. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 209641 | pGL3-MTS-G3635A-L17-FZY2-S100C-UGI-Puro | To install m.G3635 mutation on mtDNA |
| 209642 | pGL3-MTS-G3635A-L17-FZY2-S100N-UGI-Puro | To install m.G3635 mutation on mtDNA |
| 209643 | pGL3-MTS-G3635A-R16-FZY2-S100C-UGI-Puro | To install m.G3635 mutation on mtDNA |
| 209644 | pGL3-MTS-G3635A-R16-FZY2-S100N-UGI-Puro | To install m.G3635 mutation on mtDNA |
| 209645 | pGL3-MTS-G3635A-L17-FZY2-S100N-T26I&T77I-UGI-Puro | To install m.G3635 mutation on mtDNA |
| 209646 | pGL3-MTS-G3635A-L17-Q2L7-T2176C-UGI-Puro | To install m.G3635 mutation on mtDNA |
| 209647 | pGL3-MTS-G3635A-L17-Q2L7-T2176N-UGI-Puro | To install m.G3635 mutation on mtDNA |
| 209648 | pGL3-MTS-G3635A-R16-Q2L7-T2176C-UGI-Puro | To install m.G3635 mutation on mtDNA |
| 209649 | pGL3-MTS-G3635A-R16-Q2L7-T2176N-UGI-Puro | To install m.G3635 mutation on mtDNA |