Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson's disease.
Sastre D, Zafar F, Torres CAM, Piper D, Kirik D, Sanders LH, Qi LS, Schule B
Sci Rep. 2023 Oct 18;13(1):17796. doi: 10.1038/s41598-023-45078-3.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 209298 | pSUSL001T:pTRE3G-dCas9-2xKRAB-p2a-tdTomato | A lentiviral vector with tetracycline-inducible system to control expression of S. aureus dCas9 (with tdTomato) to silencing specific genes due to interference with gene transcription machinery. |
| 209299 | pSUSL002R:pTRE3G-dCas9-2xKRAB-p2a-TurboRFP | A lentiviral vector with tetracycline-inducible system to control expression of S. aureus dCas9 (with RFP) to silencing specific genes due to interference with gene transcription machinery. |